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Chapter
Acknowledgments
Acknowledgments in Outlive provides readers with a heartfelt and behind-the-scenes look at the collaborative effort and personal resilience that helped bring the book to life. Originally placed on hold in early 2020 due to setbacks with the manuscript submission, the project faced considerable obstacles when the authors were let down by their book agent and publisher. However, Michael Ovitz’s timely intervention became a pivotal moment, helping revitalize the project and enabling it to move forward.…-
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Introduction
Introduction to the narrator’s journey begins with a recurring dream that captures his feelings of inadequacy and helplessness, where he attempts to catch falling eggs on a city sidewalk—an endeavor that symbolizes his relentless but futile attempts to save patients during his surgical training at Johns Hopkins Hospital. The dream unfolds with him chasing after the eggs, which represent his efforts to intervene and save lives, but despite his best efforts, every egg shatters upon hitting the ground.…-
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Chapter 1 introduces the central theme of longevity by exploring the deeply personal experiences of a physician who has witnessed death in its various forms, shaping his understanding of medicine and aging. The author recalls a pivotal moment during medical school when he encountered patient death for the first time, an experience that profoundly impacted his perspective on healthcare. This moment, followed by years of seeing both acute and chronic deaths during his residency at Johns Hopkins, led him to…
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Chapter 2 presents a bold and transformative vision for the evolution of healthcare, arguing that the medical field must adapt to effectively manage chronic diseases, which the author identifies as the defining health challenge of our era. The chapter opens with a personal anecdote from the author's time in medical residency, illustrating his frustration with the rigid structures and deeply entrenched traditions that dictate medical training. He highlights how these outdated practices create an environment…
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Chapter 3 of Objective, Strategy, Tactics – A Road Map for Reading This Book explores the importance of taking a structured, strategic approach to health and longevity. The chapter begins with the author reflecting on a funeral he attended, where he observed the significant physical and cognitive decline that often accompanies aging. This experience highlights a common trajectory in later life—one where individuals, despite their earlier years of independence, gradually lose their ability to function…
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Chapter 4 of The Longevity Paradox takes an in-depth look at centenarians—those who live to 100 or beyond—and examines the factors contributing to their remarkable lifespans. The chapter opens with entertaining stories about these long-lived individuals, some of whom attribute their longevity to habits that contradict conventional health advice, such as drinking alcohol daily or consuming bacon regularly. While these anecdotes may seem surprising, they challenge common beliefs about aging, suggesting…
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Chapter 5 of Eat Less, Live Longer? The Science of Hunger and Health explores the discovery of rapamycin and its potential impact on human health and longevity. The chapter begins with the author's journey to Easter Island with three companions, drawn by their interest in the origins of this unique compound. Initially extracted from the island’s soil in 1964 by a Canadian research team, rapamycin was further studied by scientist Suren Sehgal, who identified its antifungal properties. What started as a…
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Chapter 6 of The Crisis of Abundance explores the widening gap between human evolution and modern dietary habits, focusing on the rapid rise of nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic steatohepatitis (NASH). These conditions have increased alongside obesity and metabolic disorders, often progressing unnoticed due to their subtle or nonexistent early symptoms. Originally identified in individuals with excessive fructose intake rather than alcohol consumption, the…
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Chapter
Chapter 7: The Ticker: Confronting—and Preventing—Heart Disease, the Deadliest Killer on the Planet
Chapter 7 of The Ticker delves into the hidden dangers of cardiovascular disease (CVD), emphasizing its gradual development and the critical need for early intervention. The author recounts his personal experience with heart disease, revealing a strong family history of cardiac conditions that shaped his awareness of its risks. Despite adopting a healthy lifestyle, his medical evaluations exposed underlying vulnerabilities, highlighting that CVD is not solely influenced by diet and exercise but is also…-
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Chapter 8 of The Runaway Cell – New Ways to Address the Killer That Is Cancer begins with the remarkable case of James DeAngelo, a patient from the late 1960s who unexpectedly survived metastatic stomach cancer despite receiving no medical treatment. His survival puzzled doctors and led researcher Steve Rosenberg to explore the role of the immune system in combating cancer, a theory that was largely unproven at the time. Despite facing numerous setbacks and failures in his research, Rosenberg's…
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